The Effect of Biological Clock & Molecular Clock in Cancer

Seyed Mohammad Amin Kormi, Gholamreza Motalleb , Mohammad Amin Kerachian

Seyed Mohammad Amin Kormi
Cancer Genetics Research Unit, Reza Radiation Oncology Center, Mashhad, Iran

Gholamreza Motalleb
Institution of Biotechnology, University of Zabol, Zabol, Iran. Email:

Mohammad Amin Kerachian
3. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
Online First: November 01, 2016 | Cite this Article
Kormi, S., Motalleb, G., Kerachian, M. 2016. The Effect of Biological Clock & Molecular Clock in Cancer. The Cancer Press 2(4): 64-66. DOI:10.15562/tcp.30

Nowadays change in lifestyle can most effect in our health, such as Insomnia & circadian rhythm changes. In this mini-review article, we focus on the circadian rhythm changes and cancer. Our study was shown to us, existence any changes in the circadian rhythm and biological clock leads to various changes in the levels of melatonin in the human body. Melatonin in Human cells, it is responsible for the adjustment of the circadian rhythm and produced in pineal glands. Disruption in levels of melatonin definitely related to cancers, such as ovary, uterus, prostate, endometrium, leukemia, breast cancer. Circadian rhythm controlled by 8 important and mainly genes that related to apoptosis, cell cycle, and checkpoint. Changes in this genes significantly related to cancers. Finally, these results are obtained that the change in the biological clock, causing a change in the molecular clock. Following the regular sleep pattern, a major role in human health.


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