Original Article

Identification of Novel MicroRNAs and Their Targets in Leukemia Cancers: A Computational Approach

Adham Fani Maleki, Balal Sadeghi , Mohammad Hadi Sekhavati, Habib MotieGhader

Adham Fani Maleki
Embryonic and Stem Cell Biology and Bio-technology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.

Balal Sadeghi
Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.. Email: Sadeghi.balal@gmail.com

Mohammad Hadi Sekhavati
Department of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Habib MotieGhader
Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Online First: October 02, 2015 | Cite this Article
Fani Maleki, A., Sadeghi, B., Sekhavati, M., MotieGhader, H. 2015. Identification of Novel MicroRNAs and Their Targets in Leukemia Cancers: A Computational Approach. The Cancer Press 1(1): 14-18. DOI:10.15562/tcp.5

MicroRNAs (miRNAs), one of the most abundant groups of regulatory non coding RNAs in multicellular organisms, play important roles in many fundamental cellular processes. More than four hundred miRNAs have been identified in humans and the deregulated expression of miR-NA has been also shown in many cancers. Despite the postulated in-volvement of miRNAs in tumourigenesis, there are only a few exam-ples where an oncogene or a tumour suppressor has been identified as a miRNA target. Here, we present an in silico analysis of potential miR-NA- MYC interactions. We showed evidence for the regulation of c-MYC, one of the most potent and frequently deregulated oncogenes, via the predicted binding site in transcriptional and post transcriptional re-gions. In this work, bioinformatics approach for the prediction and vali-dation of possible targets for miRNAs has been used. A list of putative targets is available and validation of which would be experimentally validated.
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