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68Ga-PSMA-11 PET-CT is superior to bone scintigraphy for detection bone metastasis in low and high grade of prostate cancer

Habibollah Dadgar

Habibollah Dadgar
Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran. Email:
Online First: April 03, 2019 | Cite this Article
Dadgar, H. 2019. 68Ga-PSMA-11 PET-CT is superior to bone scintigraphy for detection bone metastasis in low and high grade of prostate cancer. The Cancer Press 5(1, 2, 3, 4): 34-40. DOI:10.15562/tcp.72

Bone with distant metastasis and morbidity due to skeletal complications is a lesion that encouraged many authors to focus on the new radiotracers for better diagnosis regarding high sensitivity and specificity. However, 99mTc-Methylene diphosphonate (MDP) bone scintigraphy (BS) is the current standard imaging due to increase adsorption of the tracer at osteoblastic sites; it shows false-positives in degenerative changes and false-negatives in bone marrow metastasis. Recently, Prostate Specific Membrane Antigen (PSMA) is the promising target in prostate cancer imaging due to the over-expression in cancer cells. 68Ga-PSMA-11, a small molecule with PSMA enzyme inhibition activity has to benefit in bone and lymph-node recurrences and staging. Moreover, as degenerative changes do not have PSMA uptake will have not positive in response to therapy, the bone scan has enough quality for degenerative changes. With this consideration, BS is unable to differentiate bone metastasis from degenerative changes. 68Ga-PSMA-11 could overcome this limitation from conventional imaging as well. Finally, we concluded that PSMA PET-CT would have better sensitivity and specificity due to the unique distinction for detecting metastases. 

Keywords: bone scan, 68Ga-PSMA PET, metastasis


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