Review Article

Biomarkers of Non Alcoholic Steatohepatitis: a systematic review and meta-analysis

Azra Izanloo, Kamran Ghaffarzadehgan , Seyed Majid Sadrzadeh, Zahra Behrooznia, Seyed Saleh Tabatabaie

Azra Izanloo
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad,Iran

Kamran Ghaffarzadehgan
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran. Email:

Seyed Majid Sadrzadeh
Hasheminejad Hospital. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Behrooznia
Student Research Committee, Faculty of Medicine, Mashhad Islamic Azad University, Mashhad, Iran

Seyed Saleh Tabatabaie
ENT-HNS Research Center, HazratRasoolAkram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Online First: April 03, 2019 | Cite this Article
Izanloo, A., Ghaffarzadehgan, K., Sadrzadeh, S., Behrooznia, Z., Tabatabaie, S. 2019. Biomarkers of Non Alcoholic Steatohepatitis: a systematic review and meta-analysis. The Cancer Press 5(1, 2, 3, 4): 15-25. DOI:10.15562/tcp.73

Introduction: NAFLD is a common cause of chronic liver disease worldwide. Progression of chronic liver disease leads to liver transplant, so theearly detection of the primary stages is of utmost importance. This study aims to perform a systematic review of pertinent literature to determine early stages of NASH and explorediagnostic biomarkers of ck-18 family.

Method: This study is systematic and Meta analysis. We searched articles of different levels published in pub med, Cochrane collaboration library until December 9, 2016. Two independent reviewers assessed articles according to predefined criteria and extracted relevant data. AUC and values related to each biomarker in NASH, NO NAFLD and NAFLD groups were analyzed.

Results:The total population of five studies incorporated in the meta-analysis consisted of 345 subjects with an average age of 69.45 ± 8.40 years. The AUC related to M30 for diagnosis of NASH was reported between 0.60 and 0.88, which was suitable to differentiate NASH from simple steatohepatotitis.

Conclusion: The results showed that M30 was a suitable biomarker for the diagnosis of NASH. It is considering that the use of biomarkers can reduce the need for biopsy for the diagnosis of NASH and consequently decreaserelated costs and risks.


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